PURPOSE: The purpose of this study was to determine the effect of a 12-month jumping exercise intervention on bone mineral density (BMD) and biomarkers of bone turnover, N-telopeptide (NTX), and alkaline phosphatase (ALK PHOS) in a group of postmenopausal women. SUBJECTS: Fifty-three post-menopausal women (50 to 65 years) were recruited to participate and randomized into an exercise (EX) and a non-exercise control (CON) group. METHODS: Exercisers performed progressive atypical, multidimensional jumping on the floor and from aerobic steps (4 inch and 6 inch) a minimum of 2 days per week at 25 to 200 jumps per session. Bone mineral density of the femoral neck, total hip, and lumbar spine was measured at baseline and 12 months using dual x-ray absorptiometry (DXA). Urinary NTX and serum ALK PHOS concentrations were assayed at baseline, 6 months, and 12 months. A mixed model (group x time) multivariate analysis of variance (MANOVA) procedure was performed for each set of dependent variables BMD (3) and biomarkers (2). RESULTS: Forty-nine subjects completed the study, EX (n = 23) and CON (n = 26). Neither MANOVA showed a significant interaction between group and time. CONCLUSION: Participants in the jumping intervention in our study did not show improvement in BMD or biomarkers relative to nonparticipants.

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