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Heparin with and without graded compression stockings in the prevention of thromboembolic complications of major abdominal surgery: a randomized trial
Wille-Jorgensen P, Thorup J, Fischer A, Holst-Christensen J, Flamsholt R
The British Journal of Surgery 1985 Jul;72(7):579-581
clinical trial
6/10 [Eligibility criteria: No; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: Yes; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

One hundred and seventy-six patients scheduled for elective major abdominal surgery were randomized to two prophylactic regimens to prevent postoperative thromboembolism. All patients were screened with the 125I-labelled fibrinogen uptake test, and thromboembolism was verified by ascending phlebography and/or perfusion/ventilation lung scintigraphy. In the group of patients receiving low-dose heparin treatment (5,000 units twice daily subcutaneously) 12% developed thromboembolic complications. In the other group, where low-dose heparin treatment was supplemented with graded compression stockings only 2% developed thromboembolism. It is concluded that the combination of low-dose heparin and the use of graded compression stockings is superior to heparin alone in preventing thromboembolism following major abdominal surgery.

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