Use the Back button in your browser to see the other results of your search or to select another record.

Detailed Search Results

Small doses of subcutaneous sodium heparin in preventing deep venous thrombosis after major surgery
Nicolaides AN, Dupont PA, Desai S, Lewis JD, Douglas JN, Dodsworth H, Fourides G, Luck RJ, Jamieson CW
Lancet 1972 Oct 28;300(7783):890-893
clinical trial
5/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: Yes; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: No. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

The efficacy of small doses of peri-operative subcutaneous heparin in preventing deep venous thrombosis has been studied in a controlled clinical trial involving 251 patients undergoing major operations. The results indicate that the regimen of sodium heparin used was safe. It reduced the frequency of postoperative deep venous thrombosis from 24% in the control group to 0.8% in the test group as detected by the 125I-fibrinogen test. In addition it reduced the frequency of the dangerous extensive thrombi often responsible for pulmonary emboli from 7.4% to nil.

Full text (sometimes free) may be available at these link(s):      help