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Physical training improves insulin resistance syndrome markers in obese adolescents |
Kang HS, Gutin B, Barbeau P, Owens S, Lemmon CR, Allison J, Litaker MS, Le NA |
Medicine and Science in Sports and Exercise 2002 Dec;34(12):1920-1927 |
clinical trial |
4/10 [Eligibility criteria: No; Random allocation: Yes; Concealed allocation: No; Baseline comparability: No; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: No; Intention-to-treat analysis: Yes; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed* |
INTRODUCTION: The purpose of this study was to test the hypothesis that physical training (PT), especially high-intensity PT, would have a favorable effect on components of the insulin resistance syndrome (IRS) in obese adolescents. METHODS: Obese 13- to 16-yr-olds (N = 80) were randomly assigned to one of the following 8-month interventions; (1) lifestyle education (LSE)-alone every 2 wk, (2) LSE+moderate-intensity PT, and (3) LSE+high-intensity PT. PT was offered 5 d/wk. Plasma triacylglycerol (TAG), total cholesterol (TC), high-density lipoprotein cholesterol (HDLC), very low-density lipoprotein cholesterol (VLDLC), low-density lipoprotein cholesterol (LDLC), low-density lipoprotein (LDL)) particle size, apolipoproteins AI and B, glucose, insulin, and blood pressure were measured with standardized methods. RESULTS: The intent-to-treat analyses for all subjects who completed pre- and post-tests regardless of their adherence to the interventions showed that the LSE+high-intensity PT group had more favorable changes than the LSE-alone group in TAG level (p = 0.012), TC/HDLC (p = 0.013), and diastolic blood pressure (p = 0.031). For efficacy analyses, all PT subjects who attended at least 2 d/wk (40%) were combined into one group (LSE+PT) and compared with the LSE-alone group. These two-group analyses showed significant interactions (p < 0.001) between baseline values and group membership for deltaTAG, deltaVLDLC, and deltaTC/HDLC, such that subjects who had the least favorable baseline values showed the most beneficial impact of the PT. Of particular interest was a favorable effect of the PT on LDL particle size. CONCLUSION: PT, especially high-intensity PT, had a favorable effect on several IRS markers in obese adolescents.
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