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The effects of intermittent compression on edema in postacute ankle sprains
Rucinski TJ, Hooker DN, Prentice WE Jr, Shields EW Jr, Cote-Murray DJ
The Journal of Orthopaedic and Sports Physical Therapy 1991 Aug;14(2):65-69
clinical trial
4/10 [Eligibility criteria: No; Random allocation: Yes; Concealed allocation: No; Baseline comparability: No; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

The purpose of this study was to compare the effects of three treatment protocols on pitting edema in patients with first- and second-degree sprained ankles. Thirty subjects with postacute (> 24 hours postinjury) ankle sprains and pitting edema but not requiring cast immobilization were randomly assigned to an elastic wrap group (n = 10), an intermittent compression group (n = 10), or an elevated control group (n = 10). Pretreatment and posttreatment volumetric measurements of the subjects' ankles were obtained by the water displacement method. After the pretreatment measurement, the groups were treated for 30 minutes. All subjects ankles were elevated by raising the foot section of an adjustable table to a 45' angle during treatment. For the first treatment group, the intermittent compression device was set at 40 to 50 mmHg, with a 60-second on time and a 15-second off time. For the second treatment group, an elastic wrap was applied from the heads of the metatarsals to 12.7 centimeters above the malleoli. Control group subjects received only the elevated position as their treatment. A three by two repeated measures ANOVA with a follow-up post hoc test revealed that the elevated control group subjects had the least amount of edema (p < 0.0006). The two compression protocols produced increased edema in the subjects sprained ankles following treatment. In conclusion, elevation is the most appropriate of the three treatment protocols if the major therapeutic objective is to minimize edema in the postacute phase of rehabilitation.

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