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| Training and detraining effects of a combined-strength and aerobic exercise program on blood lipids in patients with coronary artery disease |
| Tokmakidis SP, Volaklis KA |
| Journal of Cardiopulmonary Rehabilitation 2003 May-Jun;23(3):193-200 |
| clinical trial |
| 5/10 [Eligibility criteria: No; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed* |
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PURPOSE: The aim of this study was to investigate training and detraining effects on blood lipids and apolipoproteins induced by a specific program that combined strength and aerobic exercise in patients with coronary artery disease (CAD). METHODS: For this study, 14 patients participated in a supervised 8-month training program composed of two strength sessions (60% of 1 repetition maximum) and two aerobic training sessions (60% to 85% of maximum heart rate), and 13 patients served as a control group. Blood samples for total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), apolipoproteins A1 (apo-A1) and B (apo-B), and lipoprotein (a) (Lpa) were obtained along with muscular strength at the beginning of the study, after 4 and 8 months of training and after 3 months of detraining. RESULTS: The patients in the intervention group showed favorable alterations after 8 months of training (TC -9.4; TG -18.6; HDL-C 5.2; apo-A1 11.2%; p < 0.05), but these were reversed after 3 months of detraining (TC +3.7; TG 16.1; HDL-C -3.6; apo-A1 -5.5%). In addition, body strength also improved after training (27.8%) but reversed (-12.9%) after detraining (p < 0.05). The patients in the control group did not experience any significant alterations. CONCLUSIONS: The results indicate that an 8-month training program combining strength and aerobic exercise induces favorable muscular and biochemical adaptations, on TC, TG, HDL-C, and apo-A1 levels, protecting patients with CAD. After 3 months of detraining, however, the favorable adaptations were reversed, underscoring the need of uninterrupted exercise throughout life.
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