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Effects of acute exercise on mood and well-being in patients with major depressive disorder
Bartholomew JB, Morrison D, Ciccolo JT
Medicine and Science in Sports and Exercise 2005 Dec;37(12):2032-2037
clinical trial
4/10 [Eligibility criteria: Yes; Random allocation: No; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

PURPOSE: This study was designed to determine if a single bout of moderate-intensity aerobic exercise would improve mood and well-being in 40 (15 male, 25 female) individuals who were receiving treatment for major depressive disorder (MDD). METHODS: All participants were randomly assigned to exercise at 60 to 70% of age-predicted maximal heart rate for 30 min or to a 30-min period of quiet rest. Participants completed both the Profile of Mood States (POMS) and Subjective Exercise Experiences Scale (SEES) as indicators of mood 5 min before, and 5, 30, and 60 min following their experimental condition. RESULTS: Both groups reported similar reductions in measures of psychological distress, depression, confusion, fatigue, tension, and anger. Only the exercise group, however, reported a significant increase in positive well-being and vigor scores. CONCLUSION: Although 30 min of either moderate-intensity treadmill exercise or quiet rest is sufficient to improve the mood and well-being of patients with MDD, exercise appears to have a greater effect on the positively valenced states measured.

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