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Continuous positive airway pressure delivered by face mask in infants with the idiopathic respiratory distress syndrome: a controlled study
Rhodes PG, Hall RT
Pediatrics 1973 Jul;52(1):1-5
clinical trial
3/10 [Eligibility criteria: No; Random allocation: No; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: No; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

A controlled trial of the use of CPAP delivered by face mask was conducted in infants with IRDS. A significant difference in survival (p < 0.05) was noted in treated (all of 13) compared with control patients (seven of 11) with birth weights greater than 1,500 gm. Groups were comparable according to birth weight, gestational age, initial blood gases, and age of entry into the study. The mean duration of therapy was 32.4 hours. Complications were confined to difficulteis with mask fit and local skin care.
Reproduced with permission from Pediatrics. Copyright by the American Academy of Pediatrics.

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