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A comparative study of amphetamine, ephedrine-atropine mixture, placebo and behavioral conditioning in the treatment of nocturnal enuresis
Wright L, Craig SC
The Journal of the Oklahoma State Medical Association 1974 Oct;67(10):430-433
clinical trial
2/10 [Eligibility criteria: No; Random allocation: Yes; Concealed allocation: No; Baseline comparability: No; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: No; Point estimates and variability: No. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

Twenty-one enuretic children between four and ten years of age were randomly assigned to receive either pad and bell conditioning or medication treatment. The conditioning group maintained a significant decrease in wettings per week after four weeks. The drug group showed an initial decrease in wettings which could not be maintained. This change was interpreted as primarily placebo effect.

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