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What types of hypertensives respond better to mild exercise therapy?
Kinoshita A, Urata H, Tanabe Y, Ikeda M, Tanaka H, Shindo M, Arakawa K
Journal of Hypertension 1988 Dec;6(4 Suppl):S631-S633
clinical trial
1/10 [Eligibility criteria: No; Random allocation: Yes; Concealed allocation: No; Baseline comparability: No; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: No; Intention-to-treat analysis: No; Between-group comparisons: No; Point estimates and variability: No. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

Twenty-one patients with essential hypertension were treated with aerobic (lactate threshold) exercise (n = 21) and the change in blood pressure was compared with that in a non-exercising hypertensive control group (n = 10). After 10 weeks of exercise therapy blood pressure in the exercise group was significantly reduced, from 154 +/- 3/100 +/- 2 to 141 +/- 3/93 +/- 3 mmHg, and there was a significant reduction in plasma volume, cardiac index and plasma noradrenaline whereas there were no changes in the non-exercise group. Responders (10 mmHg or more fall in mean blood pressure) in the exercise group had a significantly higher cardiac index, serum Na:K ratio and lower total peripheral resistance in pretraining studies than non-responders. In conclusion, exercise at lactate threshold is effective in lowering blood pressure in those mild hypertensives with higher cardiac index and serum Na:K ratio.
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