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Muscle strength and qualitative myosin heavy chain isoform mRNA expression in the elderly after moderate- and high-intensity weight training
Willoughby DS, Pelsue SC
Journal of Aging and Physical Activity 1998 Oct;6(4):327-339
clinical trial
5/10 [Eligibility criteria: No; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

This study was an attempt to determine the effects of 12 weeks of moderate-intensity (MIEX) and high-intensity (HIEX) weight training on the muscular strength and qualitative myosin heavy chain (MHC) isoform mRNA expression in 18 elderly men. Subjects were randomly assigned to either a control group (Con) or training groups of either MIEX or HIEX. Training sessions occurred 3 days/week and involved three sets of 15 to 20 repetitions at 60% to 65% 1-RM for MIEX and three sets of 8 to 10 repetitions at 75% to 80% 1-RM for HIEX. Both upper and lower body strength increased for Con and increased significantly for MIEX and HIEX. No changes in MHC mRNA isoform expression were observed for Con; however, there were increases in type I MHC and decreases in type IIx MHC mRNA expression for MIEX and increases in type I, IIa, and IIx MHC mRNA expression for HIEX. The findings suggest that both moderate- and high-intensity weight training increases muscle strength and the expression of type I MHC mRNA isoform, while high-intensity weight training also increases the mRNA expression of type IIa and IIx isoforms in previously inactive elderly men.

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