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| A pilot randomised controlled trial of a home-based exercise programme aimed at improving endurance and function in adults with neuromuscular disorders |
| Dawes H, Korpershoek N, Freebody J, Elsworth C, van Tintelen N, Wade DT, Izadi H, Jones DH |
| Journal of Neurology, Neurosurgery, and Psychiatry 2006 Aug;77(8):959-962 |
| clinical trial |
| 7/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: Yes; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: Yes; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed* |
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AIM: To investigate the feasibility and effect of a home-based exercise programme on walking endurance, muscle strength, fatigue and function in people with neuromuscular disorders (NMDs). METHODS: 20 adults with NMDs recruited to a control (n = 11) or exercise (n = 9) group were assessed by blinded assessors at baseline and at week 8. Walking and strengthening exercises were given to the exercise group in an 8-week home exercise programme. A 2-min walk distance was the main outcome measurement; isometric muscle strength, fatigue and function were secondary measurements. RESULTS: 2-min walk distances were not found to change in either group (p > 0.05; control mean 14.50 (SD 22.06) m; exercise mean 2.88 (SD 20.08) m), and no difference was observed in the change scores between groups (p > 0.05). Leg muscle strength increased in the exercise group (p < 0.05) but not in the control group (p > 0.05). Significance was reached between the groups with respect to the difference in change in muscle strength scores in the right quadriceps (p < 0.05; control mean -2.82 (SD 4.87) kg; exercise mean -7.08 (SD 2.82) kg). No change was observed in fatigue or function scores (p < 0.05). CONCLUSIONS: A home-based approach aimed at improving endurance in adults with NMDs is feasible and further investigation on a larger sample is warranted.
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