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Relation of sex hormones to bone mineral density in middle-aged men during a 4 year exercise intervention trial
Huuskonen J, Vaisanen SB, Kroger H, Jurvelin JS, Penttila I, Alhava E, Rauramaa R
Bone 2002 Jul;31(1):51-56
clinical trial
5/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

Recent studies have emphasized the symbiotic role of estradiol and testosterone on bone metabolism. Several anthropomorphic-, lifestyle-, and dual-energy x-ray (DXA)-derived parameters were measured with respect to estradiol (E2), testosterone (T), free T (fT), and sex hormone-binding globulin (SHBG) in 140 men (aged 53 to 62 years) participating in a controlled, randomized exercise intervention trial. After 4 years of intervention, 132 (94.3%) men remained as participants. During the period of study, aerobic threshold increased significantly in the exercise intervention group compared with the reference group (13.4% versus -1.9%: p < 0.023). Serum E2 and fT were not convincingly related to bone mineral density (BMD) or BMD change. Aerobic threshold or the change in aerobic threshold were not associated with sex hormone or SHBG levels. Body mass index was a significant determinant of T (beta = -0.337), fT (beta = -0.293), and SHBG (beta = -0.306), and smoking predicted T (beta = 0.231) and fT (beta = 0.245). Alcohol intake was a significant determinant of E2 (beta = 0.213). Ultimately there was no convincing relation between sex hormone levels and BMD or BMD change in middle-aged men.
With permission from Excerpta Medica Inc.

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