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Earlier discharge with community-based intervention for low birth weight infants: a randomized trial
Casiro OG, McKenzie ME, McFadyen L, Shapiro C, Seshia MM, MacDonald N, Moffatt M, Cheang MS
Pediatrics 1993 Jul;92(1):128-134
clinical trial
5/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: Yes; Baseline comparability: No; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

BACKGROUND: Prolonged hospitalization of low birth weight infants increases the risk of medical and psychosocial complications. The feasibility of earlier discharge with community-based follow-up of infants of <= 2,000 g birth weight, without the use of home apnea monitors, was investigated. METHODS: One hundred infants of <= 2,000 g birth weight were randomized to either an intervention or control group. Intervention infants were discharged when readiness criteria were met. Based on assessed need, intervention group families received public health nursing and homemaker services for up to 8 weeks. Control infants were discharged to their homes at the discretion of the attending physician. All infants were assessed blindly at age 1 year with the Bayley and Home Observation for Measurement of the Environment (HOME) scales. RESULTS: There were no group differences in baseline infants' characteristics or in neonatal complications. Infants in the intervention group were discharged from the hospital at an earlier postconceptional age (mean +/- SD 36.6 +/- 1.5 weeks versus 37.3 +/- 1.6 weeks; p < 0.04). Median length of hospital stay (23 days versus 31.5 days) and mean weight at the time of discharge (2,200 +/- 288 g versus 2,275 +/- 301 g) were lower, but not significantly, for infants in the intervention group. A secondary analysis by birth weight strata (<= 1,500 g and 1,501 through 2,000 g) revealed that the most significant reductions in hospital stay and weight at discharge were realized in infants of 1,501 through 2,000 g birth weight. The persistence of apneic episodes and need for electronic monitoring prevented earlier discharge of infants of <= 1,500 g birth weight. Postdischarge services to the intervention group included 185 public health nurse home visits (3.8 +/- 0.91), 410 phone contacts (8.4 +/- 5), and 2,298 homemaker hours (46 +/- 78) of service. At 1 year, there were no deaths and no group differences in rehospitalization rates, use of ambulatory services, or Bayley scores. Intervention families had significantly higher 1-year HOME scores. Minimum cost of hospital care was $873 per day, while the total cost of community-based services averaged $626 per infant. CONCLUSIONS: A significant reduction in average length of hospital stay was achieved for infants of 1,501 through 2,000 g birth weight. Earlier discharge of infants weighing <= 1,500 g at birth was hampered by persistent apneic episodes and feeding difficulties. A community-based program designed to provide individualized support and education for families of low birth weight infants was cost-effective and had a positive influence on the home environment.
Reproduced with permission from Pediatrics. Copyright by the American Academy of Pediatrics.

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