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Broncodilatacao induzida pelo fenoterol em asmaticos: comparacao entre nebulizador a jato e espacador (Bronchodilation induced by fenoterol in asthmatic patients: comparison of jet nebulization and spacer device) [Portuguese]
Morrone N, Freire JA, Pereira CA, Ferreira AK
Revista Paulista de Medicina [Sao Paulo Medical Journal] 1990;108(2):83-87
clinical trial
3/10 [Eligibility criteria: No; Random allocation: Yes; Concealed allocation: No; Baseline comparability: No; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: No. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

OBJECTIVE: To compare bronchodilation attained by fenoterol administered through a jet nebulizer and through a spacer device. TYPE OF STUDY: Open, randomized. PATIENTS: 44 adults with asthma, peak-flow rate varying between 120 and 200 l/min. Patients were divided into two groups. TREATMENT: Group A was treated with fenoterol (2.5 mg) with saline to complete 3 ml given through a jet nebulizer; 30 minutes later, an additional dose (1 mg) was given through a 500 ml spacer. Group B was treated with the same dosage, but the spacer was used first. EVALUATION: Peak-flow meter in zero, 30 and 60 minutes. RESULTS: No significant difference in bronchodilation was seen between groups A and B. CONCLUSION: Fenoterol through a spacer can replace inhalation in adult asthma patients with non-severe obstruction. Lower cost and home treatment are the main advantages.

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