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Mechanisms of oxygen effects on exercise in patients with chronic obstructive pulmonary disease
Stein DA, Bradley BL, Miller WC
Chest 1982 Jan;81(1):6-10
clinical trial
4/10 [Eligibility criteria: No; Random allocation: Yes; Concealed allocation: No; Baseline comparability: No; Blind subjects: Yes; Blind therapists: No; Blind assessors: No; Adequate follow-up: No; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

Administration of supplemental oxygen significantly improved exercise tolerance in patients with chronic obstructive pulmonary disease. This was achieved by a reduction of ventilatory requirements for the same work load, such that limiting ventilatory capacity was not achieved until later in incremental work. Breathing supplemental oxygen produced lower levels of lactate, but relief of anaerobiasis did not contribute to ventilatory changes, since potential acid-base alterations were balanced by concomitant retention of carbon dioxide.

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