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Acceleration of wound healing with high voltage, monophasic, pulsed current
Kloth LC, Feedar JA
Physical Therapy 1988 Apr;68(4):503-508
clinical trial
4/10 [Eligibility criteria: No; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: No; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

The purpose of this study was to determine whether high voltage electrical stimulation accelerates the rate of healing of dermal ulcers. Sixteen patients with stage IV decubitis ulcers, ranging in age from 20 to 89 years, participated in the study. The patients were assigned randomly to either a treatment group (n = 9) or a control group (n = 7). Patients in the treatment group received daily electrical stimulation from a commercial high voltage generator. Patients in the control group had the electrodes applied daily but received no stimulation. The ulcers of patients in the treatment group healed at a mean rate of 44.8% a week and healed 100% over a mean period of 7.3 weeks. The ulcers of patients in the control group increased in area an average of 11.6% a week and increased 28.9% over a mean period of 7.4 weeks. The results of this study suggest that high voltage stimulation accelerates the healing rate of stage IV decubitis ulcers in human subjects.

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