OBJECTIVE: To compare the effects of a neutral wrist and metacarpophalangeal (MCP) splint with a wrist cock-up splint, with and without exercises, for the treatment of carpal tunnel syndrome (CTS). DESIGN: A 2x2x3 randomized factorial design with 3 main factors: splint (neutral wrist and MCP and wrist cock-up), exercise (exercises, no exercise), and time (baseline, 4 wk, 8 wk). SETTING: Subjects were evaluated in an outpatient hand therapy clinic. PARTICIPANTS: Sixty-one subjects with mild to moderate CTS; 51 subjects completed the study. INTERVENTIONS: There were 4 groups: the neutral wrist and MCP group and the neutral wrist and MCP-exercise group received fabricated customized splints that supported the wrist and MCP joints; the wrist cock-up group and the wrist cock-up-exercise group received wrist cock-up splints. The neutral wrist and MCP-exercise and wrist cock-up-exercise groups also received tendon and nerve gliding exercises and were instructed to perform exercises 3 times a day. All subjects were instructed to wear the assigned splint every night for 4 weeks. MAIN OUTCOME MEASURES: We used the CTS Symptom Severity Scale (SSS) and the Functional Status Scale (FSS) to assess CTS symptoms and functional status. RESULTS: Analysis of variance showed a significant main effect for splint and time on the SSS (p < 0.001, p = 0.014) and FSS (p < 0.001, p = 0.029), respectively. There were no interaction effects. CONCLUSIONS: Our results validate the use of wrist splints for the treatment of CTS, and suggest that a splint that supports the wrist and MCP joints in neutral may be more effective than a wrist cock-up splint.

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