Use the Back button in your browser to see the other results of your search or to select another record.

Detailed Search Results

PUVA therapy versus Goeckerman therapy in the treatment of psoriasis: a pilot study
Williams R
Physiotherapy Canada 1985 Nov-Dec;37(6):361-366
clinical trial
3/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: No; Blind subjects: No; Blind therapists: No; Blind assessors: Yes; Adequate follow-up: No; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: No. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

For years, ultraviolet radiation therapy in combination with photosensitizers such as tar derivatives has been known to be beneficial in the treatment of psoriasis. A more recent treatment is photochemotherapy, also referred to as PUVA, which involves the interaction of light (UVA or long-wave ultraviolet light) and a drug (psoralens). The purpose of this study was to compare the effectiveness of PUVA with that of conventional UVB (middle-wave ultraviolet light) and topical far derivatives (Goeckerman regimen) on patients with psoriasis. In this pilot study, six patients were randomly assigned to either the PUVA therapy or the Goeckerman regimen. Treatment outcome was evaluated on the basis of pre-and post-assessment of the percentage of the body coverage by psoriatic lesions, as well as by the patient's ability to achieve a 95% improvement. Although no statistically significant differences were found between the two interventions, the overall trend appears to show a greater improvement with PUVA therapy.

Full text (sometimes free) may be available at these link(s):      help