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Effect of intensive neurodevelopmental treatment in gross motor function of children with cerebral palsy
Tsorlakis N, Evaggelinou C, Grouios G, Tsorbatzoudis C
Developmental Medicine and Child Neurology 2004 Nov;46(11):740-745
clinical trial
7/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: Yes; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: Yes; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

This study examined the effect of neurodevelopmental treatment (NDT) and differences in its intensity on gross motor function of children with cerebral palsy (CP). Participants were 34 children (12 females, 22 males; mean age 7 y 3 mo (SD 3 y 6 mo), age range 3 to 14y) with mild to moderate spasticity and hemiplegia (n = 10), diplegia (n = 12), and tetraplegia (n = 12). Gross Motor Function Classification System levels were: I (n = 10), II (n = 10), and III (n = 14). The paired sample, which was obtained by ratio stratification and matching by sex, age, and distribution of impairment from a total of 114 children with CP, was assigned randomly to two groups: group A underwent NDT twice a week and group B five times a week for 16 weeks. The outcome measure used was the Gross Motor Function Measure, which assessed the performance of the children before and after intervention. The paired-sample t-test revealed that gross motor function of children from both groups improved significantly after intervention (p < 0.05). Children in group B performed better and showed significantly greater improvement than those in group A (p < 0.05). Results support the effectiveness of NDT and underline the need for intensive application of the treatment.

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