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Long-term endurance exercise decreases antiangiogenic endostatin signalling in overweight men aged 50 to 60 years [with consumer summary]
Brixius K, Schoenberger S, Ladage D, Knigge H, Falkowski G, Hellmich M, Graf C, Latsch J, Montie GI, Prede GI, Bloch W
British Journal of Sports Medicine 2008 Feb;42(2):126-129
clinical trial
3/10 [Eligibility criteria: No; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: No; Intention-to-treat analysis: No; Between-group comparisons: No; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

BACKGROUND: Endurance training may decrease the risk of coronary artery disease. It has been speculated that these effects may be due to an exercise-induced stimulation of angiogenesis. The underlying mechanisms are not yet clear. Therefore, using ELISA, we investigated the plasma level of vascular endothelial growth factor (VEGF, angiogenic factor) and endostatin (antiangiogenic factor) in a group of untrained men aged 50 to 60 years with obesity. METHODS: All men were randomised into a "running" group (training 3 times/week, 60 min each, n = 7), a "cycling" group (training 3 times/week, 90 min each, n = 7) and a sedentary control group (n = 7). Both training groups worked at moderate intensity (2 to 4 mmol/l lactate). The intervention had a duration of 6 months. Before and after this period, blood samples were taken from the participants at rest and they underwent a medical investigation. RESULTS: Body mass index (BMI), systolic and diastolic blood pressure, and plasma levels of VEGF and endostatin were comparable in all three groups. Endurance training significantly reduced BMI in both exercise groups (mean (SEM) before versus after 29.7 (0.7) versus 29.1 (0.6) kg/m2 and 31.1 (0.7) versus 30.1 (0.9) kg/m2 for the running and cycling groups respectively) but not in the control group (30.0 (1.0) versus 30.2 (0.8) kg/m2). Endurance training did not influence VEGF plasma level (before versus after 1.3 (0.4) versus 1.5 (0.2) ng/ml for the running group; 1.6 (0.3) versus 1.5 (0.2) ng/ml for the cycling group; and 2.5 (0.6) versus 2.1 (0.7) ng/ml for the control group). Plasma level of endostatin was significantly reduced in both exercise groups (mean (SEM) before versus after: 20.9 (1.6 versus 17.5 (1.0) ng/ml and 21.3 (1.4 versus 18.0 (1.6) ng/ml for the running and cycling groups respectively) but not in controls (19.7 (1.3 versus 17.7 (1.1 ng/ml). CONCLUSION: Endurance training may reduce the antiangiogenic mechanisms in men aged 50 to 60 years by reducing endostatin plasma level and this may subsequently decrease the risk of cardiovascular disease.
Reproduced with permission from the BMJ Publishing Group.

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