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Enzyme studies in muscles of patients with intermittent claudication. Effect of training
Holm J, Dahllof AG, Bjorntorp P, Schersten T
Scandinavian Journal of Clinical and Laboratory Investigation 1973;128(Suppl):201-205
clinical trial
1/10 [Eligibility criteria: No; Random allocation: Yes; Concealed allocation: No; Baseline comparability: No; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: No; Intention-to-treat analysis: No; Between-group comparisons: No; Point estimates and variability: No. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

Of 12 patients with occlusive arterial disease and intermittent claudication 6 were treated with dynamic leg exercise, 6 were controls. Training more than doubled walk tolerance and enhanced activity of muscle mitachondrial succinic oxidase and of key enzymes of glucose metabolism in muscle biopsies.

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