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Effects of motor physical therapy on bone mineralization in premature infants: a randomized controlled study
Vignochi CM, Miura E, Canani LH
Journal of Perinatology 2008 Sep;28(9):624-631
clinical trial
6/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: Yes; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

OBJECTIVE: To study the effect of physical therapy on bone mineralization, weight gain and growth in preterm infants. METHOD: After fulfilling the inclusion criteria, preterm infants were matched for gestational age and birth weight and then randomly assigned to the physiotherapy group (PG, n = 15) and control group (CG, n = 14). The PG received motor physical therapy for 15 min daily, 5 times per week until hospital discharge. Bone mineralization was measured by total body dual energy x-ray beam absorptiometry (DEXA) at the onset and end of the study. Statistical analysis was realized by ANCOVA and linear correlation tests. RESULT: The physical therapy group (PG) presented greater body weight gain per day (27.4 +/- 2.4 versus 21.01 +/- 4.4 g, p < 0.001) and length (1.3 +/- 0.3 versus 0.8 +/- 0.2 cm/week, p < 0.001) than did the control group (CG). Body composition values verified by DEXA were greater for the PG. The mean gain in bone mineral content (BMC) (mg) was greater in the PG (434 +/- 247.5 versus -8.9 +/- 11.4, p < 0.001), as was the mean bone mineral density (BMD) gain (mg/cm2) (8.4 +/- 5.6 versus -3.1 +/- 5.5, p < 0.001). The gain in bone area (BA, cm2) was 10.3 +/- 5 in the PG versus 1.5 +/- 2 in the CG (p < 0.001). The gain in lean mass (LM) (g) in the PG was also greater than in the CG (271.1 +/- 21.4 versus 109.1 +/- 1.0, p < 0.009). The fat mass (g) was similar between the groups (p = 0.432). CONCLUSION: These results showed that physiotherapy in preterm infants produced greater gains in growth, body weight, BMC, BMD, BA and LM.
Reprinted by permission from Journal of Perinatology, Macmillan Publishers Ltd.

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