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| Effects of 6 months exercise training on ventricular remodelling and autonomic tone in patients with acute myocardial infarction and percutaneous coronary intervention |
| Zheng H, Luo M, Shen Y, Ma Y, Kang W |
| Journal of Rehabilitation Medicine 2008 Oct;40(9):776-779 |
| clinical trial |
| 4/10 [Eligibility criteria: Yes; Random allocation: No; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed* |
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OBJECTIVE: To study the effects of 6 months exercise training on ventricular remodelling and autonomic tone in patients with acute myocardial infarction and percutaneous coronary intervention. DESIGN: Single-blinded randomized control trial. PARTICIPANTS: Sixty patients with acute myocardial infarction who had undergone percutaneous coronary intervention. METHODS: The exercise group followed a 6-month supervised exercise programme, while the control group received routine recommendations. All patients underwent an incremental cardiopulmonary exercise test and Doppler echocardiography at baseline and after 6 months. RESULTS: Three patients in the exercise group did not complete the programme. At 6 months follow-up, an improvement was seen in the exercise group compared with the control group regarding peak VO2 (p < 0.01), Powermax (p < 0.05), VO2 at anaerobic threshold (p < 0.01), time to reach anaerobic threshold (p < 0.05), heart rate recovery (p < 0.01), left ventricular end-diastolic diameter (p < 0.01) and left ventricular ejection fraction (p < 0.05). CONCLUSION: Six months exercise training in patients with acute myocardial infarction and percutaneous coronary intervention with mild ventricular systolic dysfunction could prevent ventricular remodelling to a certain extent, and favourable modulating sympatho-vagal balance may be an important mechanism.
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