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An open controlled assessment of osteopathic manipulation in nonspecific low-back pain
MacDonald RS, Bell CM
Spine 1990 May;15(5):364-370
clinical trial
5/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

An open controlled pilot trial on nonspecific low-back pain sufferers demonstrated responsiveness to osteopathic manipulation of some patients presenting with pain durations of 14 to 28 days. No response was demonstrated in those with shorter episodes at presentation. The advantage to manipulated patients was maximal between 1 and 2 weeks after commencing treatment, but was not discernable after 4 weeks. The demonstration of a similar responsive stratum by other investigators, with both teams totally unaware of each other's work during data collection, suggests a high degree of reliability for this finding.
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