The purpose of the present clinical trial was to investigate the relative effect, in terms of subjective and objective clinical findings, of chiropractic manipulative therapy (CMT) on the foot and ankle, as opposed to placebo ultrasound, in the treatment of primary metatarsalgia. This was a prospective, single-blind clinical trial consisting of two groups. The treatment group (group A) received CMT to the foot and ankle, while the placebo group (group B) received de-tuned ultrasound as the treatment protocol. Each group consisted of 20 systematically allocated subjects. The treatment regime consisted of a course of eight treatments, with two treatments per week over a 4-week period. Subjective and objective measurements were taken at the initial, second, third and final consultations. Although there are methodological limitations, the data collected in this pilot study suggest that using CMT on the foot and ankle may possibly be superior to placebo in the treatment of primary metatarsalgia.

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