BACKGROUND: Interventions to increase physical activity among adults with chronic illness are intended to improve quality of life and reduce disease complications or slow disease progression. OBJECTIVE: The aim of this study was to integrate quality-of-life outcomes from primary research studies testing interventions to increase physical activity among adults with chronic illness. METHODS: Extensive literature searching strategies were used to locate published and unpublished primary research testing physical activity interventions. Results were coded for studies that had at least 5 participants with chronic illness. Fixed- and random-effects meta-analytic procedures included moderator analyses. RESULTS: Eighty-five samples from 66 reports with 7,291 subjects were synthesized. The mean quality-of-life effect size for two-group comparisons (treatment versus control) was 0.11 (higher mean quality-of-life scores for treatment subjects than for control subjects). The treatment group pre-post comparison effect size was 0.27 for quality of life. Heterogeneity was modest in two-group comparisons. Most design and sample attributes were unrelated to intervention effects on quality of life. Studies that exclusively used supervised center-based exercise reported larger quality-of-life improvements than did studies that included any educational/motivational content. Effect sizes were larger among unpublished and unfunded studies. The effect size for physical activity did not predict the quality-of-life effect size. DISCUSSION: Subjects experience improved quality of life from exposure to interventions designed to increase physical activity, despite considerable heterogeneity in the magnitude of the effect. Future primary research should include quality-of-life outcomes so that patterns of relationships among variables can be explored further.

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