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Einflub automatisch titrierender CPAP-systeme auf schlaf und atmung bei SAS (Effect of automatically titrated CPAP systems on sleep and respiration in sleep apnoea syndrome) [German]
Hoster M, Schlenker E, Ruhle KH
Wiener Medizinische Wochenschrift 1996;146(13-14):385-387
clinical trial
4/10 [Eligibility criteria: No; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: No; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

We compared an automated self setting CPAP-titration with conventional constant CPAP. In 12 patients with obstructive sleep apnea syndrome 2 polysomnographies were performed after introduction of CPAP-therapy. In a randomized cross-over study a constant CPAP during one night and in a second night a computerized variation of pressure was applied by a self-setting CPAP-device (Auto Adjust CPAP). During both methods apneas, hypopneas and snoring were reduced. Apnea index was reduced from 32.5 +/- 28.5 at diagnosis to 3.3 +/- 4.7 by Auto Adjust CPAP and to 4.0 +/- 5.3 by constant CPAP. The results of the 2 methods were not significantly different. Total sleep-time, sleep efficiency and sleep stages did not show any significant difference. CONCLUSIONS: In case of pressure-intolerance automated self setting CPAP offers an alternative beneath BiPAP. The significance of this method with regard to BiPAP therapy must further be evaluated.

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