Use the Back button in your browser to see the other results of your search or to select another record.

Detailed Search Results

Naproxen (Naprosyn) og mobilisering ved behandling af akut ankeldistorsion (Naproxen (Naprosyn) and mobilization in the treatment of acute ankle sprains) [Danish]
Jorgensen FR, Gotzsche PC, Hein P, Jensen CM, Nielsen BM, Nielsen FM, Ronholt EB, Tranberg FH
Ugeskrift for Laeger 1986 May 19;148(21):1266-1268
clinical trial
3/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: No; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: No. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

In a double-blind study the effect of naproxen (Naprosyn) and early mobilization was investigated in 173 patients with acute, simple sprained ankles. A statistically significant effect of naproxen was shown as regards pain on weightbearing, pain on palpation, active mobility, number of days till complete pain relief and duration of sick leave. Patients with no walking sticks, ie, early mobilization, had significantly better results than patients with two sticks with respect to active mobility, number of recovered patients and sick leave. Measured by foot volumetry, the greatest inflammatory oedema occurred in the subgroup treated with two walking sticks and a placebo. Side-effects were few and mild (five patients in the naproxen group and four patients in the placebo group). The most important finding from this study was that both early mobilization and treatment with 1,000 mg naproxen daily were capable of reducing the duration of sick leave.

Full text (sometimes free) may be available at these link(s):      help