PURPOSE: To investigate the effects of a 12-week home walking program on cardiovascular parameters, fatigue perception, and walking distance in persons with multiple sclerosis (MS). METHODS: Fifteen ambulatory persons with MS, not currently participating in exercise were randomly assigned to control (C) or experimental groups (EX). Pretest data collection included resting HR, BP, fatigue perception (Fatigue Severity Scale), and 6-minute walk test. EX received a home walking program (30 min, 3 x week, x 12 weeks), using a modification of Karvonen's formula to calculate HR range. A HR monitor was used to adjust walking speed. The C group refrained from any regular exercise. Posttest data were collected at week 12 and analyzed using the Mann-Whitney U Test. RESULTS: No statistically significant differences were noted between groups in any measured parameters; however, walking distance and Physiologic Cost Index did improve in the exercise group. CONCLUSION: No adverse events or increase in fatigue levels related to the exercise intervention were reported in this study. This home walking program may not be of sufficient intensity to elicit significant cardiovascular changes. Abnormal cardiac responses have been documented in this population, which may have affected the results. Clinicians may need to use alternate measures to assess fitness in this population.

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