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Effects of a low-frequency sound wave therapy programme on functional capacity, blood circulation and bone metabolism in frail old men and women [with consumer summary]
Zheng A, Sakari R, Cheng SM, Hietikko A, Moilanen P, Timonen J, Fagerlund KM, Karkkainen M, Alen M, Cheng S
Clinical Rehabilitation 2009 Oct;23(10):897-908
clinical trial
7/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: Yes; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: Yes; Adequate follow-up: No; Intention-to-treat analysis: Yes; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

OBJECTIVE: To evaluate the effects of a low-frequency sound wave therapy programme on functional capacity, blood circulation and bone metabolism of the frail elderly. DESIGN: Single-blind, randomized, controlled trial. SETTING: Two senior service centres. SUBJECTS: Forty-nine volunteers (14 males and 35 females) aged 62 to 93 years with up to 12 diagnosed diseases were allocated in either the intervention group (n = 30) or control group (n = 19). INTERVENTION: The intervention group underwent sound wave therapy, 3 to 5 times a week for 30 minutes per session over a period of 6 months. The control group received no intervention. MAIN MEASUREMENTS: Blood pressure, functional capacity, mobility, bone density, biochemical markers, isometric muscle strength, balance, and skin surface temperature. RESULTS: Compared with the control group, the intervention group's mobility and the amount of self-reported kilometres walked per week increased by 3 km (p < 0.05), while levels of cholesterol (4.97 (0.72) to 4.52 (0.65) mmol/L, p = 0.019), low-density lipoprotein (2.82 (0.72) to 2.45 (0.61) mmol/L, p = 0.022), bone markers of total osteocalcin (11.0 (6.5) to 10.3 (5.9) ng/mL, p = 0.048)) and tartrate-resistant acid phosphatase isoform 5b (2.50 (1.0) to 2.41 (1.1) IU/L, p = 0.021)) decreased. The average skin surface temperature was significantly higher during active sessions at the end of the intervention than in the beginning (p = 0.004). No change was found during placebo sessions. CONCLUSIONS: Low-frequency sound wave therapy may have the potential to promote well-being of frail elderly subjects via improved functional capacity, especially in subjects who are too frail to undertake exercise.

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