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Kann man die analgetische wirkung der mobilisin-salbe durch die iontophorese verstarken? Plazebokontrollierte dreifach-cross-over-doppelblindstudie (Does the iontophoresis intensify the analgesic effect of Mobilisin ointment? Placebo-controlled double-blind three-way crossover trial) [German]
Pavelka K Jr, Pavelka K Sr, Svarcova J, Vacha J, Trnavsky K
Zeitschrift fuer Rheumatologie 1988 Jul;47(4):233-237
clinical trial
8/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: Yes; Baseline comparability: Yes; Blind subjects: Yes; Blind therapists: No; Blind assessors: Yes; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

In a double-blind, three-way crossover trial, with placebo controls on 41 patients with inflammatory rheumatic disorders (mono- or oligo-articular forms), the analgesic action of Mobilisin ointment, with or without iontophoresis, was significantly stronger than after iontophoresis alone or after placebo. Iontophoresis did not potentiate the analgesic properties of Mobilisin. The pain was scored on VAS in intervals 30 min, 1, 2, 4, 6, 8 h after application. The duration of analgesic effect after Mobilisin procedures was 6.5 h on average, which was significantly longer than after iontophoresis alone or after placebo.

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