Use the Back button in your browser to see the other results of your search or to select another record.

Detailed Search Results

Community-based randomized controlled trial of non-pharmacological Interventions in prevention and control of hypertension among young adults
Saptharishi L-G, Soudarssanane M-B, Thiruselvakumar D, Navasakthi D, Mathanraj S, Karthigeyan M, Sahai A
Indian Journal of Community Medicine 2009 Oct;34(4):329-334
clinical trial
6/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: Yes; Intention-to-treat analysis: Yes; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

CONTEXT: Hypertension is a major chronic lifestyle disease. Several non-pharmacological interventions are effective in bringing down the blood pressure (BP). This study focuses on the effectiveness of such interventions among young adults. AIMS: To measure the efficacy of physical exercise, reduction in salt intake, and yoga, in lowering BP among young (20 to 25) pre-hypertensives and hypertensives, and to compare their relative efficacies. SETTINGS AND DESIGN: The study was done in the urban service area of JIPMER. Pre-hypertensives and hypertensives, identified from previous studies, constituted the universe. The participants were randomized into one control and three interventional groups. MATERIALS AND METHODS: A total of 113 subjects: 30, 28, 28 and 27 in four groups respectively participated for eight weeks: control (I), physical exercise (II) -- brisk walking for 50 to 60 minutes, four days/week, salt intake reduction (III) -- to at least half of their previous intake, and practice of yoga (IV) -- for 30 to 45 minutes/day on at least five days/week. STATISTICAL ANALYSIS USED: Efficacy was assessed using paired t test and ANOVA with Games Howell post hoc test. An intention to treat analysis was also performed. RESULTS: A total of 102 participants (29, 27, 25 and 21 in groups I, II, III and IV) completed the study. All three intervention groups showed a significant reduction in BP (SBP/DBP: 5.3/6.0 in group II, 2.6/3.7 in III, and 2.0/2.6 mmHg in IV respectively). There was no significant change (SBP/DBP: 0.2/0.5 mmHg) of BP in control group (I). Physical exercise was most effective (considered individually); salt intake reduction and yoga were also effective. CONCLUSIONS: Physical exercise, salt intake reduction, and yoga are effective non-pharmacological interventions in significantly reducing BP among young hypertensives and pre-hypertensives. These can therefore be positively recommended for hypertensives. There is also a case to deploy these interventions in the general population.

Full text (sometimes free) may be available at these link(s):      help