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| Cost-utility of a cardiovascular prevention program in highly educated adults: intermediate results of a randomized controlled trial |
| Jacobs N, Evers S, Ament A, Claes N |
| International Journal of Technology Assessment in Health Care 2010 Jan;26(1):11-19 |
| clinical trial |
| 5/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: Yes; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: No; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed* |
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OBJECTIVES: Little is known about the costs and the effects of cardiovascular prevention programs targeted at medical and behavioral risk factors. The aim was to evaluate the cost-utility of a cardiovascular prevention program in a general sample of highly educated adults after 1 year of intervention. METHODS: The participants were randomly assigned to intervention (n = 208) and usual care conditions (n = 106). The intervention consisted of medical interventions and optional behavior-change interventions (eg, a tailored web site). Cost data were registered from a healthcare perspective, and questionnaires were used to determine effectiveness (eg, quality-adjusted life-years (QALYs)). A cost-utility analysis and sensitivity analyses using bootstrapping were performed on the intermediate results. RESULTS: When adjusting for baseline utility differences, the incremental cost was Euro 433 and the incremental effectiveness was 0.016 QALYs. The incremental cost-effectiveness ratio was 26,910 Euro /QALY. CONCLUSIONS: The intervention was cost-effective compared with usual care in this sample of highly educated adults after 1 year of intervention. Increased participation would make this intervention highly cost-effective.
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