OBJECTIVE: To evaluate the efficacy of the Nijmegen Falls Prevention Program (NFPP) for persons with osteoporosis and a fall history in a randomized controlled trial. Persons with osteoporosis are at risk for fall-related fractures because of decreased bone strength. A decrease in the number of falls therefore is expected to be particularly beneficial for these persons. DESIGN: Randomized controlled trial. SETTING: Hospital. PARTICIPANTS: Persons with osteoporosis and a fall history (n = 96; mean +/- SD age 71.0 +/- 4.7y; 90 women). INTERVENTION: After baseline assessment, participants were randomly assigned to the exercise (n = 50; participated in the NFPP for persons with osteoporosis (5.5wk)) or control group (n = 46; usual care). MAIN OUTCOME MEASURES: Primary outcome measure was fall rate, measured by using monthly fall calendars for 1 year. Secondary outcomes were balance confidence (Activity-specific Balance Confidence Scale), quality of life (QOL (Quality of Life Questionnaire of the European Foundation for Osteoporosis)), and activity level (LASA Physical Activity Questionnaire, pedometer), assessed posttreatment subsequent to the program and after 1 year of follow-up. RESULTS: The fall rate in the exercise group was 39% lower than for the control group (0.72 versus 1.18 falls/person-year; risk ratio 0.61; 95% confidence interval 0.40 to 0.94). Balance confidence in the exercise group increased by 13.9% (p = 0.001). No group differences were observed in QOL and activity levels. CONCLUSION: The NFPP for persons with osteoporosis was effective in decreasing the number of falls and improving balance confidence. Therefore, it is a valuable new tool to improve mobility and independence of persons with osteoporosis.

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