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Intervention with education and exercise reverses the metabolic syndrome in adults
Mujica V, Urzua A, Leiva E, Diaz N, Moore-Carrasco R, Vasquez M, Rojas E, Icaza G, Toro C, Orrego R, Palomo I
Journal of the American Society of Hypertension 2010 May-Jun;4(3):148-153
clinical trial
7/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: Yes; Adequate follow-up: Yes; Intention-to-treat analysis: Yes; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

About 29% of the adult population of Talca, Chile, suffers from the metabolic syndrome (MS), a value higher than the national prevalence. Evidence indicates that exercise and nutritional changes reduce the predominance of this syndrome. The goal of this study was to evaluate the effects of a structured interventional program of physical activity and nutritional counseling in adults with MS. Fifty-one subjects were studied: 27 were included in the interventional program (I-MS). The control group was formed by 24 individuals who did not participate in the program (NI-MS). We assessed body weight, corporal composition, arterial pressure, glycemia, and lipid profile at baseline and after 18 weeks of treatment. After this period, the I-SM group showed a significant decrease in triglycerides (geometric mean 202.2 to 110.5 mg/dL, p < 0.001), diastolic blood pressure (mean 85.4 to 79.6 mmHg, p = 0.001), waist circumference (mean men 101.5 to 94.1 cm, p < 0.001; mean women 107.2 to 96.2 cm, p < 0.001), weight (mean 81.1 to 77.2 kg, p < 0.001), and body mass index (mean 31.8 to 30.2 kg/m2, p < 0.001). In the NI-MS group, the individual parameters did not change significantly. Our results show that a non-pharmacological treatment based on exercise exerts an important beneficial effect in patients with MS, mainly on the waist circumference, blood pressure, and triglycerides.

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