OBJECTIVE: The purpose of this study was to compare adaptations in functional and quality of life measures following endurance- and resistance-exercise training in people with multiple sclerosis. DESIGN: Cross-over design with an eight-week washout period. SETTING: Community health centre. SUBJECTS: Sixteen individuals with multiple sclerosis. INTERVENTION: Subjects completed both an eight-week endurance- and an eight-week resistance-exercise training programme in a randomized order. The exercise training comprised individualized progressive programmes that were completed twice weekly in a supervised group setting. MAIN MEASURES: Grip strength, functional reach, four step square, timed up and go and six-minute walk tests, Multiple Sclerosis Impact and Modified Fatigue Impact Scales, Becks Depression Inventory and the Health Status Questionnaire Short Form-36. RESULTS: Sixteen of 21 (76%) subjects completed the study. Subjects attended 13.2 +/- 1.6 endurance- and 15.8 +/- 1.9 resistance-exercise training sessions. No adverse events were reported. No significant differences (p < 0.05) in any outcome measures were observed between the two exercise training programmes either at baseline or following the completion of both training programmes. CONCLUSION: Both endurance- and resistance-exercise training were well tolerated and appear to provide similar effects for people with multiple sclerosis, but larger studies are required to confirm these findings.

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