CONTEXT: High-voltage pulsed current (HVPC), a form of electrical stimulation, is known to curb edema formation in laboratory animals and is commonly applied for ankle sprains, but the clinical effects remain undocumented. OBJECTIVE: To determine whether, as an adjunct to routine acute and subacute care, subsensory HVPC applied nearly continuously for the first 72 h after lateral ankle sprains affected time lost to injury. DESIGN: Multicenter, randomized, double-blind, placebo-controlled trial. SETTING: Data were collected at 9 colleges and universities and 1 professional training site. PARTICIPANTS: 50 intercollegiate and professional athletes. INTERVENTIONS: Near-continuous live or placebo HVPC for 72 h postinjury in addition to routine acute and subacute care. MAIN OUTCOME MEASURE: Time lost to injury measured from time of injury until declared fit to play. RESULTS: Overall, time lost to injury was not different between treated and control groups (p = 0.55). However, grade of injury was a significant factor. Time lost to injury after grade I lateral ankle sprains was greater for athletes receiving live HVPC than for those receiving placebo HVPC (p = 0.049), but no differences were found between groups for grade II sprains (p = 0.079). CONCLUSIONS: Application of subsensory HVPC had no clinically meaningful effect on return to play after lateral ankle sprain.
Copyright Human Kinetics. Reprinted with permission from Human Kinetics (Champaign, IL).

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