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Increases in thigh muscle volume and strength by walk training with leg blood flow reduction in older participants
Ozaki H, Sakamaki M, Yasuda T, Fujita S, Ogasawara R, Sugaya M, Nakajima T, Abe T
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 2011 Mar;66(3):257-263
clinical trial
4/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: No; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

We examined the effects of walk training combined with leg blood flow reduction (BFR) on muscle hypertrophy as well as on peak oxygen uptake (VO2peak) in older individuals. Both the BFR walk training (BFR-Walk, n = 10, age; 64 +/- 1 years, body mass index (BMI); 22.5 +/- 0.9 kg/m2) and control walk training (CON-Walk, n = 8, age; 68 +/- 1 years, BMI; 23.2 +/- 1.0 kg/m2) groups performed 20 minutes of treadmill walking at an exercise intensity of 45% of heart rate reserve, 4 days per week, for 10 weeks. The BFR-Walk group wore pressure belts (160 to 200 mmHg) on both legs during training. After the training, magnetic resonance imaging-measured thigh muscle cross-sectional area (3.1%, p < 0.01) and muscle volume (3.7%, p < 0.01) as well as maximal isometric (5.9%, p < 0.05) and isokinetic (up to 22%, p < 0.01) strength increased in the BFR-Walk group, but not in the CON-Walk group. Estimated VO2peak during a bicycle graded exercise test increased (p < 0.05) and correlated with oxygen pulse in both groups. In conclusion, BFR walk training improves both muscle volume and strength in older women.
Copyright the Gerontological Society of America. Reproduced by permission of the publisher.

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