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Comparison of the effect of upper body-ergometry aerobic training versus treadmill training on central cardiorespiratory improvement and walking distance in patients with claudication
Bronas UG, Treat-Jacobson D, Leon AS
Journal of Vascular Surgery 2011 Jun;53(6):1557-1564
clinical trial
5/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: No; Intention-to-treat analysis: Yes; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

BACKGROUND: Supervised treadmill-walking exercise programs have been proven to be a highly effective in improving walking distance in peripheral arterial disease (PAD) patients with lifestyle-limiting claudication. Limited information is available on the contributions of central cardiorespiratory functions for improving these patients' walking capacity with exercise training. METHODS: This study randomized 28 participants (21 men; age 65.6 years; 92.7% smoking history, 36.6% with diabetes) with lifestyle-limiting PAD-related claudication to 3 hours/week of supervised exercise training for 12 weeks, using arm-ergometry (n = 10) or treadmill-walking (n = 10) versus a usual-care control group (n = 8). Cardiorespiratory function measurements were assessed before and after training at a submaximal workload and at the onset of claudication (pain-free walking distance (PFWD)) and at maximal walking distance (MWD). Changes in these functions from baseline were analyzed among the groups with analysis of covariance. Associations between variables were determined by Pearson's partial correlations. RESULTS: The mean baseline demographic, medical, and exercise variables were similar among the groups. There were similar significant differences in the submaximal double product (heart rate x systolic blood pressure) and at MWD, ventilatory threshold, ventilatory oxygen uptake (VO2) at onset of claudication, and VO2peak in response to training in both exercise groups versus the control group. Statistically significant, moderate correlations (r = 0.60 to 0.68) were found between changes in all cardiorespiratory variables and changes in PFWD or MWD. CONCLUSION: Improvements in cardiorespiratory function after arm-ergometry or treadmill-training were significantly associated with improvements in both PFWD and MWD, providing supporting evidence of systemic contributions to exercise training-related improvements in walking capacity seen in patients with claudication.

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