The purpose of this randomized controlled trial was to determine the effects of an 8-week (aerobic+strength) exercise training program (3 sessions/week) on the circulating cytokine levels of breast cancer survivors. We randomly allocated 16 female survivors of breast cancer (mean +/- SD age 50 +/- 5 years) to an intervention or usual care (control) group (n = 8 in each group). The intervention group followed an 8-week exercise program consisting of 3 sessions/week (session duration: 90min). We measured the levels of the following cytokines before and after the intervention: beta-NGF, CTACK, eotaxin, FGF basic, G-CSF, gmCSFalpha, HGF, ICAM1, IFNalpha2, IFNgamma, IL1alpha, IL1s, IL1ra, IL2, IL2ra, IL3, IL4, IL6, IL7, IL8, IL9, IL10, IL12, IL13, IL15, IL16, IL17, IL18, IP10, LIF, MCS-F, MIP1alpha, MIP1beta, MIF, MCP1, MCP3, MIG, PDGF bb, SCF, SCGFbeta, SDF1alpha, TRAIL, TNFalpha, TNFbeta, VCAM1, and VEGF. We only observed a significant interaction (group x time) effect for CTACK (p = 0.016), with mean values remaining stable in the intervention group but increasing over time in controls. The intervention program did not induce a significant decrease in the main breast cancer-related cytokines such as IL6 and IL8. A combined (aerobic+strength) 8-week exercise training intervention did not induce major changes in the basal cytokine levels of breast cancer survivors.

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