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| Pneumatic compression of the calf and postoperative deep-vein thrombosis |
| Clark WB, MacGregor AB, Prescott RJ, Ruckley CV |
| Lancet 1974 Jul 6;304(7871):5-7 |
| clinical trial |
| 5/10 [Eligibility criteria: No; Random allocation: Yes; Concealed allocation: Yes; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: No; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed* |
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The prevention of deep-vein thrombosis (DVT) by intermittent pneumatic compression of the calf during and up to 24 hours after operation was studied by controlled trial. One leg was randomly allocated to treatment in each patient. DVT was diagnosed by 125-I-fibrinogen scanning. With a sequential statistical analysis, thirty-six patients were required before the 5% significance level was passed. Seven thrombi were detected in the control legs and none in the compressed legs. The study confirms that intermittent pneumatic compression is a safe and effective method of preventing early postoperative DVT.
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