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Invloed van fysieke training op vermoeidheid tijdens behandeling van kanker; meta-analyse van klinische trials (Physical training to reduce fatigue levels during cancer treatment; a meta-analysis of clinical trials) [Dutch]
Velthuis MJ, Agasi-Idenburg SC, van der Wall E, Aufdemkampe G, Wittink HM
Nederlands Tijdschrift voor Geneeskunde 2011;155(45):A3679
systematic review

OBJECTIVE: To investigate the safety, feasibility and effects of physical training according to various training programmes on fatigue during cancer treatment. DESIGN: Meta-analysis of randomised controlled studies. METHODS: A systematic search of CINAHL, Cochrane Library, Embase, Medline, Scopus en PEDro was carried out using the following terms: 'cancer', 'adjuvant treatment, 'exercise' and 'fatigue'. We summarised the studies using Standardised Mean Difference (SMD). RESULTS: A total of 18 studies were included (12 in breast cancer, four in prostate cancer, one in multiple myeloma and one in acute myeloid leukaemia), 1,109 patients in total. During breast cancer treatment, independent traininghome-based physical exercise lead to a small, non-significant reduction (SMD 0.10; 95% confidence interval (CI) -0.25 to 0.45), whereas supervised aerobic exercise resulted in a moderate, significant reduction in fatigue in the training group in comparison with the control group (SMD 0.30; 95% CI 0.09 to 0.51). A subgroup analysis of independent training (n = 65), supervised aerobic training (n = 98) and supervised weight training (n = 208) during treatment for prostate cancer showed no significant difference between the training group and the control group. Therapy adherence ranged from 39% (the percentage of patients who attended at least 70% of the training sessions) to 100% in participants who followed independent trainingprogramme. In more than half of the studies (12/18; 67%) attention was also paid to negative adverse effects of physical training. In total, eight negative events were reported (0.72% of 1,109). CONCLUSION: Physical exercise during treatment for breast and prostate cancer seems to be feasible, and causes no health risks. In particular, supervised aerobic exercises during breast cancer treatment seems to have promising effects on fatigue.

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