The present study assessed the effects of exercise training on biomarkers of inflammation in postinfarction patients. This single-centre prospective randomized controlled trial encompassed 42 patients after the first myocardial infarction divided into exercise-training (n = 22) or usual care (n = 20) groups. Complete randomization was performed by choosing one of 2 sealed envelopes. The exercise-training group participated in an 8-week programme comprising 3 aerobic exercise sessions per week. The control group received usual care. The main measures were changes in circulating levels of c-reactive protein, interleukin (IL)-6 and -10, soluble vascular cell adhesion molecule-1 (VCAM-1), soluble intercellular adhesion molecule-1 (ICAM-1), anthropometrics, dietary intake, daily physical activity, and cardiorespiratory fitness. 4 patients terminated the study prematurely, leaving 38 for the statistical analysis (exercise-training, n = 20; control group, n = 18). In comparison to control group, exercise-training group improved IL-10 levels (1.7 (7.0) versus -0.3 (2.4) pg/mL, p < 0.05), daily moderate-intensity physical activity (12.9 +/- 21.3 versus -0.7 +/- 13.4 min, p < 0.05), and cardiorespiratory fitness (3.0 +/- 3.5 versus 0.3 +/- 4.1 ml/min/kg, p < 0.05). Additionally, the change in VCAM-1 and ICAM-1 levels was significantly higher in the control group (respectively, 26.6 +/- 112.1 versus 94.1 +/- 90.0 ng/mL and 7.3 +/- 41.0 versus 35.0 +/- 39 ng/mL, p < 0.05). In conclusion, exercise training improved the inflammatory profile in post myocardial infarction patients by enhancing the anti-inflammatory cytokine IL-10.

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