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Intrahospital weight and aerobic training in children with cystic fibrosis: a randomized controlled trial
Santana-Sosa E, Groeneveld IF, Gonzalez-Saiz L, Lopez-Mojares LM, Villa-Asensi JR, Gonzalez MIB, Fleck SJ, Perez M, Lucia A
Medicine and Science in Sports and Exercise 2012 Jan;44(1):2-11
clinical trial
7/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: Yes; Adequate follow-up: Yes; Intention-to-treat analysis: Yes; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

PURPOSE: The purpose of our study was to assess the effects of an 8-wk intrahospital combined circuit weight and aerobic training program performed by children with cystic fibrosis (of low-moderate severity and stable clinical condition) on the following outcomes: cardiorespiratory fitness (VO2peak) and muscle strength (five-repetition maximum (5RM) bench press, 5RM leg press, and 5RM seated row) (primary outcomes) and pulmonary function (forced vital capacity, forced expiratory volume in 1 s), weight, body composition, functional mobility (Timed Up and Down Stairs and 3-m Timed Up and Go tests), and quality of life (secondary outcomes). We also determined the effects of a detraining period (4 wk) on the aforementioned outcomes. METHODS: We performed a randomized controlled trial design. Eleven participants in each group (controls: 7 boys, age 11 +/- 3 yr, body mass index 17.2 +/- 0.8 kg/m2 (mean +/- SEM); intervention: 6 boys, age 10 +/- 2 yr, body mass index 18.4 +/- 1.0 kg/m2) started the study. RESULTS: Adherence to training averaged 95.1% +/- 7.4%. We observed a significant group x time interaction effect (p = 0.036) for VO2peak. In the intervention group, VO2peak significantly increased with training by 3.9 mL/kg/min (95% confidence interval 1.8 to 6.1 mL/kg/min, p = 0.002), whereas it decreased during the detraining period (-3.4 mL/kg/min, 95% confidence interval -5.7 to -1.7 mL/kg/min, p = 0.001). In contrast, no significant changes were observed during the study period within the control group. Although significant improvements were also observed after training for all 5RM strength tests (p < 0.001 for the interaction effect), the training improvements were not significantly decreased after the detraining period in the intervention group (all p > 0.1 for after training versus detraining). We found no significant training benefits in any of the secondary outcomes. CONCLUSIONS: A short-term combined circuit weight and aerobic training program performed in a hospital setting induces significant benefits in the cardiorespiratory fitness and muscle strength of children with cystic fibrosis.

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