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Efficacy comparison of splint and oral steroid therapy in nerve conduction velocity and latency median nerve in carpal tunnel syndrome
Madjdinasab N, Zadeh NS, Assarzadegan F, Ali AMA, Pipelzadeh M
Pakistan Journal of Medical Sciences 2008 Oct-Dec;24(5 Pt 1):725-728
clinical trial
4/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: No; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

OBJECTIVES: To evaluate the effects of splinting in neutral position of the wrist and oral Prednisolone on neurophysiologic variables in patients with carpal tunnel syndrome (CTS). METHODOLOGY: This double blind study was carried out in 48 idiopathic CTS patients. They were randomly divided in two groups. Splint group (n = 24) used splint for six weeks; and steroid group (n = 24) who got oral Prednisolone 20 mg/day for two weeks. Electrophysiological evaluations were done initially for having baseline and after 1.5-months follow up. SPSS software (version 11) and independent t-test and paired t-test were used for statistical analysis. RESULTS: After six weeks median nerve motor and sensory had distal latency and their conduction velocity improved significantly in both groups (p < 0.05). There was no significant difference between both groups due to electro physiologic improvement and clinical improvement. CONCLUSION: There was significant electro physiologic improvement in both groups, at six weeks. On comparing the efficacy of the two treatment methods, there was no significant difference between the two.

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