OBJECTIVE: This study examined the feasibility, safety, and efficacy of using Tai Chi for treating major depressive disorder. DESIGN: Thirty-nine Chinese Americans with major depressive disorder were randomized into a 12-wk Tai Chi intervention or a waitlisted control group in a 2:1 ratio. The key outcome measurement was the 17-item Hamilton Rating Scale for Depression. Positive response was defined as a decrease of 50% or more on the 17-item Hamilton Rating Scale for Depression, and remission was defined as a score of 7 or lower on the 17-item Hamilton Rating Scale for Depression. RESULTS: Of the participants (n = 39), 77% were women, and mean (SD) age was 55 (10) years. There were 26 (67%) participants in the Tai Chi intervention group and 13 (33%) in the control group. Of the participants in the Tai Chi group, 73% completed the intervention; no adverse events were reported. We observed trends toward improvement in the Tai Chi intervention group, compared with the control group, in positive treatment-response rate (24% versus 0%) and remission rate (19% versus 0%), although the differences in our small sample did not reach statistical significance. CONCLUSIONS: A randomized controlled trial of Tai Chi is feasible and safe in Chinese American patients with major depressive disorder. These promising pilot study results inform the design of a more definitive trial.

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