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Effect of aerobic training on hot flushes and quality of life -- a randomized controlled trial [with consumer summary]
Luoto R, Moilanen J, Heinonen R, Mikkola T, Raitanen J, Tomas E, Ojala K, Mansikkamaki K, Nygard C-H
Annals of Medicine 2012 Sep;44(6):616-626
clinical trial
5/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

BACKGROUND AND OBJECTIVE: To estimate whether aerobic training has an effect on frequency of hot flushes or quality of life. DESIGN: A randomized controlled trial. PARTICIPANTS AND SETTING: Symptomatic, sedentary women (n = 176), 43 to 63 years, no current use of hormone therapy. INTERVENTION: Unsupervised aerobic training for 50 minutes four times per week during 6 months. OUTCOMES: Hot flushes as measured with Women's Health Questionnaire (WHQ) and Health-Related Quality of Life (HRQoL, SF-36), daily reported hot flushes on phone-based diary, cardiorespiratory fitness (CRF), and body composition. RESULTS: Intervention group had larger decrease in the frequency of night-time hot flushes based on phone diary (p for month x group 0.012), but not on WHQ scale. Intervention group had less depressed mood (p = 0.01) than control women according to change in WHQ score. Changes in WHQ score in depressed mood (p = 0.03) and menstrual symptoms (p = 0.01) in the intervention group were significantly dependent on frequency of training sessions. HRQoL was improved among the intervention group women in physical functioning (p = 0.049) and physical role limitation (p = 0.017). CRF improved (p = 0.008), and lean muscle mass increased (p = 0.046) significantly in the intervention group as compared to controls. CONCLUSIONS: Aerobic training may decrease the frequency of hot flushes and improve quality of life among slightly overweight women.

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