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Einfluss korperlicher aktivitat auf die fettoxidation und endothelfunktion bei adipasen -- eine randomisiert kontrollierte studie (Influence of physical activity on fat oxidation and endothelial function in obesity -- a randomized controlled trial) [German]
Bircher S, Mucha C
Physikalische Medizin, Rehabilitationsmedizin, Kurortmedizin 2007;17(6):313-319
clinical trial
5/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: Yes; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: No; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

PURPOSE: What are the effects of moderate physical activity based on the intensity of the highest fat oxidation rate on endothelial function, fat oxidation and body composition in obese women and men? MATERIALS AND METHODS: 26 subjects with a BMI above 30 kg/m2 were randomly assigned to a training and a control group. Subjects of the training group performed three training session per week for 45 minutes for 12 weeks based on their individually determined intensity of highest fat oxidation. Fat oxidation was determined during a treadmill test, the endothelial function was assessed by the ultrasound method on the A brachialis. In both groups the control measurements were done at the beginning and at the end of the 12 weeks lasting intervention period. RESULTS: In contrast to the control group the training group improved endothelial function from 4.33.5 to 6.9 +/- 2.7% significantly (p = 0.001). Furthermore the training group achieved a significantly (p = 0.019) improved flow mediated dilatation (FMD) and a significant higher FMD. Fat oxidation rate improved during all three stages significantly (p = 0.006; p = 0.023; p = 0.007) and fat free mass increased significantly (p = 0.009) whereas body fat mass was reduced (p = 0.003). CONCLUSION: A training program of twelve weeks based on the intensity of the highest fat oxidation improves endothelial function and fat oxidation in obese women and men even without reduction in body weight.

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