OBJECTIVES: To examine the impact of the muscle resistance program (MRP) on muscular and functional performance and on IL-6 and soluble TNF receptor-1 (sTNFr1) plasma levels in pre-frail community-dwelling women. DESIGN: Randomized clinical trial-Cross over design with a post intervention and short term follow-up. SETTING: university hospital. PARTICIPANTS: Thirty-two pre-frail community-dwelling women (>= 65 years). INTERVENTION: The muscle resistance program was designed based on the exercise at 75% of each participant's maximum load (10 week, 3 times/week). MAIN OUTCOME MEASURES: Plasma concentrations of IL-6 and sTNFr1 (high sensitivity ELISA kits); muscle strength of the knee extensors (isokinetic); functional performance (Timed Up and Go (TUG); 10-m Walk Test (10MWT)). RESULTS: There were significant differences in functional and muscular performance between the pre--muscle resistance program (pre-MRP), post-muscle resistance program (post-MRP), and a 10-week follow-up period. After the muscle resistance program, both functional (TUG, pre-MRP = 11.1 seconds versus post-MRP = 10.4 seconds, p = 0.00; 10MWT, pre-MRP = 4.9 seconds versus post-MRP = 4.4 seconds, p = 0.00) and muscular performances (pre-MRP = 77.8% and post-MRP = 83.1%, p = 0.02) improved. After cessation of muscle resistance program (follow-up period), the sTNFr1 plasma levels increased by 21.4% at the 10-week follow up (post-MRP, 406.4 pg/ml; 10 week follow up, 517.0 pg/ml; p = 0.03). There was significant differences in sTNFr1 (p = 0.01). CONCLUSION: The muscle resistance program was effective in improving functional and muscular performances, although alterations in plasma levels of IL-6 and sTNFr1 could not be identified after muscle resistance program. Cessation of the muscle resistance program during 10-week resulted in increased plasma levels of the sTNFr1.

Full text (sometimes free) may be available at these link(s):      help

• DOI
• PubMed
• PDF locator
• publisher